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Haack, Andrew K.; Sheth, Chandni; Schwager, Andrea L.; Sinclair, Michael S.; Tandon, Shashank; Taha, Sharif A. (2014)
Publisher: Public Library of Science
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Animal Models, Research Article, Anatomy, Substance-Related Disorders, Alcohol Consumption, Rodents, Mental Health and Psychiatry, Public and Occupational Health, Diet, Animals, Rats, Substance Abuse, Specimen Disruption, Biology and Life Sciences, Neuroscience, Research and Analysis Methods, Medicine, Mechanical Treatment of Specimens, Vertebrates, Specimen Preparation and Treatment, Q, R, Nutrition, Nervous System, Learning and Memory, Mammals, Model Organisms, Science, Organisms, Behavioral Neuroscience, Medicine and Health Sciences, Electroporation

Classified by OpenAIRE into

mesheuropmc: endocrine system, hormones, hormone substitutes, and hormone antagonists
The lateral habenula (LHb) plays an important role in learning driven by negative outcomes. Many drugs of abuse, including ethanol, have dose-dependent aversive effects that act to limit intake of the drug. However, the role of the LHb in regulating ethanol intake is unknown. In the present study, we compared voluntary ethanol consumption and self-administration, yohimbine-induced reinstatement of ethanol seeking, and ethanol-induced conditioned taste aversion in rats with sham or LHb lesions. In rats given home cage access to 20% ethanol in an intermittent access two bottle choice paradigm, lesioned animals escalated their voluntary ethanol consumption more rapidly than sham-lesioned control animals and maintained higher stable rates of voluntary ethanol intake. Similarly, lesioned animals exhibited higher rates of responding for ethanol in operant self-administration sessions. In addition, LHb lesion blocked yohimbine-induced reinstatement of ethanol seeking after extinction. Finally, LHb lesion significantly attenuated an ethanol-induced conditioned taste aversion. Our results demonstrate an important role for the LHb in multiple facets of ethanol-directed behavior, and further suggest that the LHb may contribute to ethanol-directed behaviors by mediating learning driven by the aversive effects of the drug.

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