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Ernesto Benítez Hechavarría; Ciro Labrada Estrada; Enriqueta Martínez Martínez; Odalis Tamayo Fuentes; Esther Díaz Pérez (2006)
Publisher: Editorial Ciencias Médicas
Journal: Revista Cubana de Farmacia
Languages: Spanish
Types: Article
Subjects: Parabenos, cromatografía líquida de alta resolución (HPLC), suspensión, Parabens, high resolution liquid chromatography (HRLC), suspension, Therapeutics. Pharmacology, RM1-950
Se realizó la valoración prospectiva de un método desarrollado para la cuantificación de metil y de propil parabeno en el gel de hidróxido de aluminio mediante cromatografía líquida de alta resolución en fase reversa, con columna RP18 (25* 0,4 cm) y detector UV-Visible a 254 nm. Se evaluaron los parámetros especificidad, linealidad, precisión, exactitud, y adecuación cromatográfica. Los resultados obtenidos mostraron que el método cumple con las especificaciones establecidas para cada parámetro evaluado, lo cual indicó que es un método rápido, seguro y confiable para la determinación cuantitativa de los parabenos en este gel
The prospective assessment of a method developed for the quantification of methyl/propyl paraben in aluminum hydroxide gel by reverse-stage high resolution liquid chromatography on RP18 column (25*0.4 cm), and with UV detector visible at 254 nm, was made. The specificity, lineality, accuracy, exactness and chromatographic adequacy were evaluated The results obtained showed that the method meets the specifications established for each evaluated parameter, which indicates that it is a rapid, safe and reliable method for the quantitative determination of the parabens in this gel

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