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Margret Chandira R; Jayakar B; Palanisamy P. (2012)
Publisher: International Research Journal of Pharmacy
Journal: International Research Journal of Pharmacy
Languages: English
Types: Article
Subjects: Effect of Binders, % Drug release., R, Medicine, DOAJ:Medicine (General), DOAJ:Health Sciences, Antituberculosis agents, Pharmacy and materia medica, DOAJ:Pharmacy and materia medica, RS1-441

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mesheuropmc: bacterial infections and mycoses
Ethambutol hydrochloride and Isoniazid Drugs are used as Antituberculosis agents. It is mainly used in the initial Treatment of pulmonary tuberculosis. Here in present study compressed tablet of Ethambutol hydrochloride and Isoniazid prepared by using HPMC, HPC, and PVPK -30 as binders. Compressed tablets of Ethambutol hydrochloride and Isoniazid were prepared by wet granulation method. Among different trials of F1 to F9 with wet granulation, the trial F1 showed satisfactory in-vitro drug release profile as compared to that of innovator for formulation. The cumulative percentage of drug release of formulation F1 (Isoniazid) And F1 (Ethambutol) were 99.53 and 99.43 respectively. The result of stability studies of batch F1 indicate that it is stable at 40°C ± 2°C / 75% RH ± 5 % relative humidity as there was no significant differences observe for dissolution and assay after two months.
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