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Jeevangi; Manjunath; Deepak D; Prakash G; Prashant; Chetan (2013)
Publisher: Akshantala Enterprises
Journal: Journal of Evolution of Medical and Dental Sciences
Languages: English
Types: Article
Subjects: Curcuma longa, Turmeric, Alloxan-induced rats, Piog litazone, Dentistry, RK1-715, Medicine, R, Medicine (General), R5-920
ABSTRACT: OBJECTIVE AND BACKGROUND: Turmeric (Curcuma longa) is one of the common constituents of our daily food. The present study wa s undertaken to evaluate the anti-diabetic effects of ethanolic extract of Rhizomes of curcuma longa in alloxan induced diabetic rats and compared with of Pioglitazone, which is the standard anti-diabetic agent. METHODS: Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mg/kg i.p. and anti-diabetic activity of turmeric was studied by f ollowing study design. The rats are divided into 6 groups and each group con tains 6 rats (N= 6) as follows. Group I: Normal control Given normal saline (10ml/kg/day). Group II: Diabetic control Given normal saline (10ml/kg/day). Group III: Euglycemic rats Given turmeric extract (300mg/kg/day ). Group IV: Diabetic rats Given turmeric extract (300mg/kg/ day). Group V: Diabetic control Given turmeric extract (500mg/kg/ day). Group VI: Diabetic rats Given Pioglitazone (6mg/kg/day) Study was conducted for a period of 28 days and all the drugs were given orally once daily. Blood glucose levels were estimated at 1, 3, 5, 7 hrs. (acute study) and 7, 14, 21, 28 days (chronic study). The body weights of the rats in ev ery groups recorded weekly and general behavior and health of the animal were monitored ca refully. The data was analyzed statistically using student’s paired and unpaired t-test. RESULTS: Ethanolic extract of turmeric produced significant ( p < 005 ) decreases in blood glucose l evels on 7 th , 14 th , 21 th and 28 days in diabetic ORIGINAL ARTICLE Journal of Evolution of Medical and Dental Sciences/ Volume 2/ Issue 11/ March 18, 2013 Page-1670 rats but there was no significant reduction in bloo d glucose levels after 1hr, 3hrs, 5hrs and 7hrs after single dose of administration of turmeric ext ract. CONCLUSION: Present study revealed that curcuma longa possesses anti-diabetic activity can used to treat diabetes patients.
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