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Muilwijk, Bas; Verheij, Simone; Pel, Johan; Boon, Andrea; Steen, Hans (2013)
Publisher: BioMed Central
Journal: Translational Neurodegeneration
Languages: English
Types: Article
Subjects: Neurology. Diseases of the nervous system, RC346-429, Research

Abstract

Objective

Many daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and hands. The aim of this study was to investigate how Parkinson’s disease (PD) affects eye-hand coordination in tasks with different cognitive complexity.

Methods

We used a touch screen, an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients (H&Y < 2.5) and age-matched controls. Timing and kinematics of eye and hand were quantified in four eye-hand coordination tasks (pro-tapping, dual planning, anti-tapping and spatial memory task).

Results

In the pro-tapping task, saccade initiation towards extrinsic goals was not impaired. However, in the dual planning and anti-tapping task initiation of saccades towards intrinsic goals was faster in PD patients. Hand movements were differently affected: initiation of the hand movement was only delayed in the pro-tapping and dual planning task. Overall, hand movements in PD patients were slower executed compared to controls.

Interpretation

Whereas initiation of saccades in an extrinsic goal-directed task (pro-tapping task) is not affected, early stage PD patients have difficulty in suppressing reflexive saccades towards extrinsic goals in tasks where the endpoint is an intrinsic goal (e.g. dual planning and anti-tapping task). This is specific for eye movements, as hand movements have delayed responses in the pro-tapping and dual planning task. This suggests that reported impairment of the dorsolateral prefrontal cortex in early-stage PD patients affects only inhibition of eye movements. We conclude that timing and kinematics of eye and hand movements in visuomotor tasks are affected in PD patients. This result may have clinical significance by providing a behavioral marker for the early diagnosis of PD.

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    • 1. Deiber MP, Ibanez V, Sadato N, Hallett M: Cerebral structures participating in motor preparation in humans: a positron emission tomography study. J Neurophysiol 1996, 75:233-247.
    • 2. de Lau LML, Breteler MMB: Epidemiology of Parkinson's disease. Lancet Neurol 2006, 5:525-535.
    • 3. Muangpaisan W, Mathews A, Hori H, Seidel D: A systematic review of the worldwide prevalence and incidence of Parkinson's disease. J Med Assoc Thai 2011, 94:749-755.
    • 4. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD: Neurodegenerative Diseases Target Large-Scale Human Brain Networks. Neuron 2009, 62:42-52.
    • 5. Savitt JM, Dawson VL, Dawson TM: Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest 2006, 116:1744-1754.
    • 6. Wu Y, Le W, Jankovic J: Preclinical biomarkers of Parkinson disease. Arch Neurol 2011, 68:22-30.
    • 7. Breen DP, Michell AW, Barker RA: Parkinsons disease-the continuing search for biomarkers. Clin Chem Lab Med 2011, 49:393-401.
    • 8. Amador SC, Hood AJ, Schiess MC, Izor R, Sereno AB: Dissociating cognitive deficits involved in voluntary eye movement dysfunctions in Parkinson's disease patients. Neuropsychologia 2006, 44:1475-1482.
    • 9. Chan F, Armstrong IT, Pari G, Riopelle RJ, Munoz DP: Deficits in saccadic eye-movement control in Parkinson's disease. Neuropsychologia 2005, 43:784-796.
    • 10. Mosimann UP, Muri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG: Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies. Brain: a journal of neurology 2005, 128:1267-1276.
    • 11. Bekkering H, Neggers SF, Walker R, Gleissner B, Dittrich WH, Kennard C: The preparation and execution of saccadic eye and goal-directed hand movements in patients with Parkinson's disease. Neuropsychologia 2001, 39:173-183.
    • 12. Adamovich SV, Berkinblit MB, Hening W, Sage J, Poizner H: The interaction of visual and proprioceptive inputs in pointing to actual and remembered targets in Parkinson's disease. Neuroscience 2001, 104:1027-1041.
    • 13. Marinelli L, Crupi D, Di Rocco A, Bove M, Eidelberg D, Abbruzzese G, Ghilardi MF: Learning and consolidation of visuo-motor adaptation in Parkinson's disease. Parkinsonism Relat Disord 2009, 15:6-11.
    • 14. Gowen E, Miall RC: Eye-hand interactions in tracing and drawing tasks. Hum Mov Sci 2006, 25:568-585.
    • 15. Crawford JD, Henriques DY, Medendorp WP: Three-dimensional transformations for goal-directed action. Annu Rev Neurosci 2011, 34:309-331.
    • 16. Tramper JJ, Gielen CC: Visuomotor coordination is different for different directions in three-dimensional space. The Journal of neuroscience: the official journal of the Society for Neuroscience 2011, 31:7857-7866.
    • 17. Hughes AJ, Daniel SE, Kilford L, Lees AJ: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992, 55:181-184.
    • 18. Dubois B, Slachevsky A, Litvan I, Pillon B: The FAB: a Frontal Assessment Battery at bedside. Neurology 2000, 55:1621-1626.
    • 19. Folstein MF, Folstein SE, McHugh PR: Mini-mental state, A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
    • 20. Hoehn MM, Yahr MD: Parkinsonism: onset, progression and mortality. Neurology 1967, 17:427-442.
    • 21. Stebbins GT, Goetz CG: Factor structure of the Unified Parkinson's Disease Rating Scale: Motor Examination section. Movement disorders: official journal of the Movement Disorder Society 1998, 13:633-636.
    • 22. Chambers JM, Prescott TJ: Response times for visually guided saccades in persons with Parkinson's disease: a meta-analytic review. Neuropsychologia 2010, 48:887-899.
    • 23. Briand KA, Hening W, Poizner H, Sereno AB: Automatic orienting of visuospatial attention in Parkinson's disease. Neuropsychologia 2001, 39:1240-1249.
    • 24. Armstrong IT, Chan F, Riopelle RJ, Munoz DP: Control of saccades in Parkinson's disease. Brain Cogn 2002, 49:198-201.
    • 25. Kingstone A, Klein R, Morein-Zamir S, Hunt A, Fisk J, Maxner C: Orienting attention in aging and Parkinson's disease: distinguishing modes of control. J Clin Exp Neuropsychol 2002, 24:951-967.
    • 26. van Stockum S, MacAskill M, Anderson T, Dalrymple-Alford J: Don't look now or look away: two sources of saccadic disinhibition in Parkinson's disease? Neuropsychologia 2008, 46:3108-3115.
    • 27. van Stockum S, Macaskill MR, Myall D, Anderson TJ: A perceptual discrimination task abnormally facilitates reflexive saccades in Parkinson's disease. Eur J Neurosci 2011, 33:2091-2100.
    • 28. Koerts J, Van Beilen M, Tucha O, Leenders KL, Brouwer WH: Executive functioning in daily life in Parkinson's disease: initiative, planning and multi-task performance. PLoS One 2011, 6:e29254.
    • 29. Kikuchi A, Takeda A, Kimpara T, Nakagawa M, Kawashima R, Sugiura M, Kinomura S, Fukuda H, Chida K, Okita N, et al: Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease. J Neurol Sci 2001, 193:29-36.
    • 30. Pierrot-Deseilligny C, Milea D, Muri RM: Eye movement control by the cerebral cortex. Curr Opin Neurol 2004, 17:17-25.
    • 31. Le Heron CJ, MacAskill MR, Anderson TJ: Memory-guided saccades in Parkinsons disease: long delays can improve performance. Exp Brain Res 2005, 161:293-298.
    • 32. Hood AJ, Amador SC, Cain AE, Briand KA, Al-Refai AH, Schiess MC, Sereno AB: Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007, 78:565-570.
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