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Hendra, Handi (2010)
Languages: Indonesian
Types: Unknown
Subjects: Cangkang Kapsul Alginat, Kadar Uap Air, Sifat-Sifat Fisik
Alginate capsule shell is a hard capsule shell which is developed as a new form of drug delivery. Alginate capsule shell has advantages over gelatin capsule, e.g. an ability to protect gastric mucose from drug irritation. Although there are many researches about alginate capsule shell, but there is no information available about the physical properties of alginate capsule shell related to moisture content. Therefore, the main objective of this research was to study the effect of moisture content on the physical properties of alginate capsule shell The effects of moisture content on physical properties of alginate capsule shells that were investigated in this research were color, disintegration time, brittleness, water vapor permeability, and equilibrium moisture content. For physical stability test, alginate capsule shells were stored at room temperature (250C, Relative Humidity/RH 60%) and 400C, RH 75% for 3 months. The effect of moisture content on the ability of microbial growth was also tested. Moisture content affected the color of alginate capsule shell. The color of alginate capsule shell was white transparent if the moisture content > 20%, and turned into yellow if the moisture content nearly 0%. In addition, moisture content affected the brittleness of alginate capsule shell. Alginate capsules became brittle if the moisture content < 16% but became soften if the moisture content > 25%. The ideal storage condition, which did not make capsule brittled was at 25oC, 70-75% RH. Alginate capsule shells didn’t disintegrate in HCl 0.1 N but disintegrated in phosphate buffer pH 6.8 after less than one hour, water vapor permeability of alginate capsule shells was 17.3 ± 0.20 mg/hr•cm2, and the equilibrium moisture content of alginate capsule shells followed isotherm type II (sigmoidal or S form). After 3 months of storage under room condition and at 400C; RH 75%, the color of alginate capsule shells turned into brown due to browning reaction. Moisture content and brittleness test in both storage conditions showed no significance difference with the initial condition. But disintegration time at 400C, RH 75% was faster than initial condition and room temperature condition. The initial water activity of alginate capsule shells was 0.34, but with the increasing moisture content from storage at RH 90%, aw capsule increased from 0.34 to 0.94. On overall, it could be concluded that moisture content affected the physical properties of alginate capsule shell. 060804038
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