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Oré, Raquel; Suárez, Silvia; Arnao, Inés (2014)
Publisher: Facultad de Medicina Humana de la Universidad Nacional Mayor de San Marcos
Languages: Spanish; Castilian
Types: Article
Subjects: Placenta; materno- fetal exchange; pre-eclampsia; phosphofructokinase; Glucosa dehydrogenase, Placenta; Pre eclampsia; Intercambio materno-fecal; fosfofructoquinasa; Gucosa deshidrogenasa
Pre eclampsia is one of the most frecuent pathologies during pregnancy. The placental tissue plays an important role in the development of the pathology. In this report we performed a study of the activities of two regulatory enzymes [ Phosphofructokinase I (E.C. 2.7.1.11) and Glucose 6-P-dehidrogenase (E.C. 1.1.1.49)] of the carbohydrate metabolism in both normal and pre emclampsia placental tissue. It has been found a pronounced decreased in both activities in the pathological tissue. We discussed the possible mechanisms. La pre eclampsia es una de las patologías más frecuentes en el embarazo. La placenta juega un papel importante en el desarrollo del cuadro. En el presente trabajo realizamos un estudio de las actividades de dos enzimas reguladoras [Fosfofructoquinasa I (C.E. 2.7.1.11). y Glucosa 6-P deshidrogenasa (C.E. 1.1.1.49) ] en el metabolismo de carbohidratos en tejido placentario normal y preeclamptico a término. Se halla una marcada disminución de las actividades de ambas enzimas en los tejidos patológicos. Se discuten los posible mecanismos.
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