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Riaño G., Nancy B.; Vera A., Victor J.; Villamil J., Luis Carlos (2007)
Publisher: Universidad de La Salle. Revistas. Revista de Medicina Veterinaria.
Languages: Spanish; Castilian
Types: Article
Subjects: Células madre; biomodelos; ciencias veterinarias, biomodelos, Stem cells; biomodels; veterinary sciences, Veterinary medicine, SF600-1100, células madre, Ciencias Veterinarias
Identifiers:doi:10.19052/mv.2040
Las características de una célula madre (stem cell) están determinadas por ser indiferenciadas, autorrenovables, y por tener la capacidad de generar células hijas para múltiples linajes celulares, con la capacidad de proliferar indefinidamente en cultivos. El origen de las células madre puede ser embrionario (blastómeros y células de la masa interna del blastocisto) o somático (células pluripotenciales de tejidos adultos). La fuente de las células madre somáticas es la médula ósea, en la cual se encuentran las células madre hematopoyéticas y las mesenquimales (MSCs). Diversos estudios en modelos animales han demostrado que MSCs constituyen una herramienta potencial para el establecimiento de terapias regenerativas en tejidos lesionados. Este artículo revisa las propiedades de las células madre, sus potenciales, sus ventajas y limitaciones en varios modelos animales. The characteristics of a stem cell are determined by being undifferentiated, auto renewable, and because of having the capacity of generating cells for multiple cellular lineages, with the capacity to proliferate indefinitely in cultures. The origin of the stem cells can be embryonic (blastomers and cells of the internal mass of the blastocyst) or somatic (pluripotential cells from adult tissues). The source of the somatic stem cells is the bone marrow, in which the hematopoietic stem cells and the mesenchymals (MSCs) are found. Diverse studies in animal models have demonstrated that MSCs constitute a potential tool for the establishment of regenerative therapies in injured tissues. This article reviews the properties of the stem cells, their potentials, their advantages and limitations in several animal models.
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