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Ketelhut, Sascha (2017)
Publisher: Freie Universität Berlin Universitätsbibliothek, Garystr. 39, 14195 Berlin
Languages: German
Types: Doctoral thesis
Subjects: 610 Medizin und Gesundheit, 610 Medical sciences; Medicine, hemodynamic parameters, high intensity intervall training, exercise intervention
ddc: ddc:610
Background: Rising body of literature recommends assessing parameters of arterial stiffness (AS) for cardiovascular risk stratification. Therefore, the goal in the present work was to assess influences of physical activity on AS. The first part of the study investigates the correlation between aerobic capacity and hemodynamic parameters at rest and during a stress test. The second part deals with the question whether a high-intensity interval training (HIIT) exerts beneficial effects on hemodynamics at rest and during stress test as own studies confirmed recently for moderate endurance training. The third part investigates whether a prevention project consisting of moderate interval training has favorable influences on AS already in children. Methods: In healthy volunteers, selected hemodynamic parameters were measured at rest and at the end of a cold pressor test (CPT) using the Mobil-O-Graph (I.E.M.). The results were evaluated due to the subjects' maximal oxygen consumption (VO2max) during a cardio pulmonary exercise test. In a second study, hemodynamic measurements were performed at rest and during CPT. Following a HIIT (6 x 1 minute with 98% of previously determined maximum wattage, 4 minutes rest between intervals) parameters were assessed throughout 60 minutes of rest and thereafter during a second CPT. In a controlled intervention, 46 students were randomized into intervention (INT) and control class (CON). Throughout 9 months, INT received additional moderate interval training (2 x 45 minutes per week) on top of the regular physical education classes (3 x 45 minutes per week). Hemodynamic measurements were recorded and compared before and after intervention. Results: There was a negative correlation between VO2max and parameters of AS at rest and during CPT as well. Compared to measurements before exercise, peripheral and central blood pressure (BP) where significantly lower until 45 minutes after HIIT. Both peripheral and central BP were significantly lower during CPT after HIIT as well when compared with CPT before HIIT. In the longitudinal study, peripheral and central BP and pulse wave velocity were lower in INT after intervention when compared with pre-intervention. In contrast, CON displayed an increase in all parameters. Conclusion: The results demonstrate an inverse relation between VO2max and hemodynamic parameters. Furthermore, a single bout of HIIT achieved positive hemodynamic effects and thus may represent an alternative to traditional endurance training. Regular physical activity improves AS and should already be performed regularly in early childhood for primary cardiovascular prevention. An interval training with moderate intensity seems advisable already in this young age.
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