LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lin, Chun-Chieh (2013)
Publisher: eScholarship, University of California
Types: Doctoral thesis
Subjects: UCSD Dissertations, Academic Chemistry. (Discipline)

Classified by OpenAIRE into

mesheuropmc: body regions, humanities
Chapter 1. The background of peptides as therapeutics and anti-cancer agents is discussed in this chapter. The development for peptide synthesis via both solution and solid phase is introduced as well as the macrocyclization strategies. Chapter 2. Sansalvamide A (SanA) exhibits anti -cancer potency in the micromolar range against multiple cancer cell lines. Structure-activity relationship (SAR) and the mechanistic studies of SanA have been investigated in our lab. This chapter focuses on the design and synthesis of SanA derivatives. Five SanA derivatives were designed based on the lead compounds in SanA project. The synthesis of these derivatives was accomplished via both solution and solid phase peptide synthesis. Studies for SAR and mechanism of action are also discussed in this chapter. Chapter 3. The novel macrocyclic peptide Urukthapelstatin A (Ustat A) possesses a unique scaffold featuring five directly-linked azoles. Ustat A exhibits nanomolar cytotoxicity against cancer cells yet its mechanism of action remains undefined. This chapter focuses on the synthesis of Ustat A and its derivatives. The design of Ustat A derivatives is depicted and the synthestic approaches are illustrated. In addition, several strategies for cyclizing the Ustat A macrocycle are discussed. Finally, the cytotoxicity of synthetic Ustat A and its fragments is also demonstrated

Share - Bookmark

Cite this article