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Publisher: The Rockefeller University Press
Journal: The Journal of Cell Biology
Languages: English
Types: Article
Subjects: Research Articles, Article

Classified by OpenAIRE into

mesheuropmc: carbohydrates (lipids), hormones, hormone substitutes, and hormone antagonists, nutritional and metabolic diseases, endocrine system
Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in ?3-adrenoceptor?stimulated glucose uptake in brown adipose tissue. We show that ?3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2?stimulated translocation of newly synthesized GLUT1 to the plasma membrane, leading to increased glucose uptake. Both parts are essential for ?3-adrenoceptor?stimulated glucose uptake. Importantly, the effect of ?3-adrenoceptor on mTOR complex 2 is independent of the classical insulin?phosphoinositide 3-kinase?Akt pathway, highlighting a novel mechanism of mTOR complex 2 activation.

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Funded by projects

  • NHMRC | Control of glucose uptake...
  • NHMRC | Alteration of glucose met...
  • ARC | Characterisation of insulin...

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