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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Back, D J; Breckenridge, A M; MacIver, M; Orme, M; Purba, H S; Rowe, P H; Taylor, I (1982)
Languages: English
Types: Article
Subjects: Research Article

Classified by OpenAIRE into

mesheuropmc: hormones, hormone substitutes, and hormone antagonists
Identifiers:pmc:PMC1402099
1 Five patients have been studied to determine the contribution of the gut wall to the pre-systemic metabolism of ethinyloestradiol. All patients had a catheter inserted into their hepatic portal vein as part of their surgical management. 2 After an oral dose of 50 micrograms (65 microCi) ethinyloestradiol, blood samples were taken from the hepatic portal vein and from a peripheral vein at intervals for 1 h. 3 In each patient the concentration of conjugated ethinyloestradiol in the portal vein was considerably higher than in the peripheral vein. 4 Although a number of assumptions have been made, calculations showed that the gut wall appeared to be twice as effective as the liver in conjugating ethinyloestradiol on the first pass. 5 In two patients there was no evidence of major uptake or metabolism of ethinyloestradiol in the lung.

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