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Sato, Junya; Kogure, Atushi; Kudo, Kenzo (2016)
Publisher: BioMed Central
Journal: Journal of Pharmaceutical Health Care and Sciences
Languages: English
Types: Article
Subjects: Inhalation, Stereoscopic-type, Pleated-type, Adsorption, Research Article, Anticancer drug exposure, Cyclophosphamide, Activated carbon, Medical mask

Classified by OpenAIRE into

mesheuropmc: cardiovascular system, heterocyclic compounds
Background The exposure of healthcare workers to anticancer drugs such as cyclophosphamide (CPA) is a serious health concern. Anticancer drug pollution may spread outside biological safety cabinets even when a closed system is used. The inhalation of vaporized anticancer drugs is thought to be the primary route of exposure. Therefore, it is important that healthcare workers wear masks to prevent inhalation of anticancer drugs. However, the permeability of medical masks to vaporized anticancer drugs has not been examined. Furthermore, the performance differences between masks including activated carbon with chemical adsorptivity and non-activated carbon masks are uncertain. We investigated activated carbon mask permeability to vaporized CPA, and assessed whether inhibition of vaporized CPA permeability was attributable to the masks? adsorption abilities. Methods A CPA solution (4?mg) was vaporized in a chamber and passed through three types of masks: Pleated-type cotton mask (PCM), pleated-type activated carbon mask (PAM), and stereoscopic-type activated carbon mask (SAM); the flow rate was 1.0?L/min for 1?h. The air was then recovered in 50?% ethanol. CPA quantities in the solution were determined by liquid chromatography time-of-flight mass spectrometry. To determine CPA adsorption by the mask, 5?cm2 of each mask was immersed in 10?mL of CPA solution (50?2500??g/mL) for 1?h. CPA concentrations were measured by high-performance liquid chromatography with ultraviolet detection. Results For the control (no mask), 3.735???0.543??g of CPA was recovered from the aerated solution. Significantly lower quantities were recovered from PCM (0.538???0.098??g) and PAM (0.236???0.193??g) (p?

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