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Cao, Y; Keum, N N; Chan, A T; Fuchs, C S; Wu, K; Giovannucci, E L (2015)
Publisher: Nature Publishing Group
Journal: British Journal of Cancer
Languages: English
Types: Article
Subjects: Epidemiology, colorectal adenoma, television watching, sedentary behaviour
Background: Prolonged TV watching, a major sedentary behaviour, is associated with increased risk of obesity and diabetes and may involve in colorectal carcinogenesis. Methods: We conducted a cross-sectional analysis among 31?065 men with ?1 endoscopy in the Health Professionals Follow-up Study (1988?2008) to evaluate sitting while watching TV and its joint influence with leisure-time physical activity on risk of colorectal adenoma. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Prolonged sitting while watching TV was significantly associated with increased risk of colorectal adenoma (n=4280), and adjusting for physical activity or a potential mediator body mass index did not change the estimates. The ORs (95% CIs) across categories of TV watching (0?6, 7?13, 14?20, and 21+?h per week) were 1.00 (referent), 1.09 (1.01?1.17), 1.16 (1.06?1.27), and 1.10 (0.97?1.25) (OR per 14-h per week increment=1.11; 95% CI: 1.04?1.18; P trend=0.001). Compared with the least sedentary (0?6?h per week of TV) and most physically active (highest quintile) men, the most sedentary (14+?h per week) and least active (lowest quintile) men had a significant increased risk of adenoma (OR=1.25; 95% CI: 1.05?1.49), particularly for high-risk adenoma. Conclusions: Prolonged TV viewing is associated with modest increased risk of colorectal adenoma independent of leisure-time physical activity and minimally mediated by obesity.

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