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Manfrini, Nicola; Guerini, Ilaria; Citterio, Andrea; Lucchini, Giovanna; Longhese, Maria Pia (2010)
Publisher: American Society for Biochemistry and Molecular Biology
Languages: English
Types: Article
Subjects: DNA and Chromosomes

Classified by OpenAIRE into

mesheuropmc: enzymes and coenzymes (carbohydrates), fungi, biological phenomena, cell phenomena, and immunity
Identifiers:pmc:PMC2857040
Meiotic recombination requires the formation of programmed Spo11-dependent DNA double strand breaks (DSBs). In Saccharomyces cerevisiae, the Sae2 protein and the Mre11-Rad50-Xrs2 complex are necessary to remove the covalently attached Spo11 protein from the DNA ends, which are then resected by so far unknown nucleases. Here, we demonstrate that phosphorylation of Sae2 Ser-267 by cyclin-dependent kinase 1 (Cdk1) is required to initiate meiotic DSB resection by allowing Spo11 removal from DSB ends. This finding suggests that Cdk1 activity is required for the processing of Spo11-induced DSBs, thus providing a mechanism for coordinating DSB resection with progression through meiotic prophase. Furthermore, the helicase Sgs1 and the nucleases Exo1 and Dna2 participate in lengthening the 5′-3′ resection tracts during meiosis by controlling a step subsequent to Spo11 removal.
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